Phospho.ELM Result

a database of S/T/Y phosphorylation sites

Epidermal growth factor receptor kinase substrate 8 (Upon binding to EGF receptor enhances EGF-dependent mitogenic signals)

Seq-ID:

Q08509 [Mus musculus]

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Interaction Network(s):

External Source(s):

MINT Interaction(s):

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GO-Terms:

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Molecular Function	Cellular Component	Biological Process
protein binding	N-methyl-D-aspartate selective glutamate receptor complex, synaptosome, postsynaptic density	behavioral response to ethanol, actin cytoskeleton reorganization, adult locomotory behavior

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	484	LSTEHSNVSDYPPADGYAYSS	-	15592455	HTP	0.09	-	-	0.48	-	medium
Y	490	NVSDYPPADGYAYSSSMYHRG	-	15592455	HTP	0.03	-	-	0.45	-	medium
Y	492	SDYPPADGYAYSSSMYHRGPH	-	15592455	HTP	0.17	-	-	0.48	-	medium

Epidermal growth factor receptor kinase substrate 8 (Upon binding to EGF receptor enhances EGF-dependent mitogenic signals)

Seq-ID:

Q12929 [Homo sapiens]

Download:

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
SH3/SH2 adaptor activity		epidermal growth factor receptor signaling pathway, cell proliferation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	476	HQRKQEIKRLSTEHSSVSEYH	-	18669648	HTP	0.27	-	-	0.56	-	medium
Y	525	PTSNRHIDRNYEPLKTQPKKY	-	18083107	HTP	0.16	-	-	0.67	-	medium
S	659	KVPANITRQNSSSSDSGGSIV	-	17081983	HTP	0.18	-	-	0.78	-	medium
S	659	KVPANITRQNSSSSDSGGSIV	-	18669648	HTP	0.18	-	-	0.78	-	medium
S	662	ANITRQNSSSSDSGGSIVRDS	-	18669648	HTP	0.24	-	-	0.81	-	medium
Y	774	RTVCPEGARVYSQITVQKAAL	-	18083107	HTP	0.99	-	-	0.38	-	medium
S	811	QEKISAAASDSGVESFDEGSS	-	17081983	HTP	0.29	-	-	0.58	-	medium
S	815	SAAASDSGVESFDEGSSH	-	17081983	HTP	0.26	-	-	0.60	-	medium